Dr. Cheng-Cheng Deng is an Associate Professor at Dermatology Hospital, Southern Medical University. He graduated from Sun Yat-sen University in 2017 with a Ph.D degree. His current research focuses on exploring the role of fibroblasts, immune cells and vascular endothelial cells in the progress of skin wound healing and abnormal scars. His studies have led to multiple publications in high-impact journals, including Nature Communications, Cancer Research, British Journal of Dermatology and Journal of Investigative Dermatology. He have served as reviewers for Journal of Investigative Dermatology, Experimental Dermatology and Journal of Gene Medicine.
Publications
1. Deng CC#, Xu XY#, Zhang Y#, Liu LC, Wang X, Chen JY, Yao LY, Zhu DH*, Yang B*. Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases. Front Immunol. 2025 Jan 13;15:1522076.（IF=5.7）
2. Pan H#, Song J#, An Q, Chen J, Zheng W, Zhang L, Gu J, Deng C*, Yang B*. Inhibition of Ubiquitin C-Terminal Hydrolase L1 Facilitates Cutaneous Wound Healing via Activating TGF-β/Smad Signalling Pathway in Fibroblasts. Exp Dermatol. 2024 Oct;33(10):e15186.(IF=3.5)
3. Deng CC#, Zhang LX#, Xu XY#, Zhu DH, Cheng Q, Ma SF, Rong ZL*, Yang B*. Risk single-nucleotide polymorphism-mediated enhancer–promoter interaction drives keloids through long noncoding RNA down expressed in keloids. British Journal of Dermatology, 2023, 23;188(1):84-93. (IF=11)
4. Gu JJ#, Deng CC#, Feng QL, Liu J, Zhu DH, Cheng Q, Rong Z*, Yang B*. Relief of Extracellular Matrix Deposition Repression by Downregulation of IRF1-Mediated TWEAK/Fn14 Signaling in Keloids. Journal of Investigative Dermatology. 2023 Jan 28:S0022-202X(23)00026-X. (IF=5.7)
5.Chen JY, Feng QL, Pan HH, Zhu DH, He RL, Deng CC*, Yang B. An Open-Label, Uncontrolled, Single-Arm Clinical Trial of Tofacitinib, an Oral JAK1 and JAK3 Kinase Inhibitor, in Chinese Patients with Keloid. Dermatology. 2023;239(5):818-827.(IF=3)
6.Song J, Zhang Y, Pan H, Xu X, Deng CC*, Yang B. Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue. J Vis Exp. 2023 Jul 28;(197).(IF=1.2)
7. Feng QL#, Gu JJ#, Chen JY, Zheng WY, Pan HH, Xu XY, Deng CC*, Yang B*. TSP1 promotes fibroblast proliferation and extracellular matrix deposition via the IL6/JAK2/STAT3 signalling pathway in keloids. Experimental Dermatology, 2022, 31(10):1533-1542. (IF=3.5)
8. Deng CC#, Hu YF#, Zhu DH#, Cheng Q, Gu JJ, Feng QL, Zhang LX, Xu YP, Wang D, Rong ZL*, Yang B*. Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases. Nature Communications, 2021, 12(1):3709. (IF=14.7)
9. Deng CC#, Zhu DH#, Chen YJ, Huang TY, Peng Y, Liu SY, Lu P, Xue YH, Xu YP, Yang B*, Rong ZL*. TRAF4 promotes fibroblast proliferation in keloids by destabilizing p53 via interacting with the deubiquitinase USP10. Journal of Investigative Dermatology, 2019, 139(9): 1925-1935. (IF=5.7)
10. Deng CC#, Lin YX#, Qi XK#, He GP, Zhang YC, Zhang HJ, Xu M, Feng QS, Bei JX, Zeng YX*, Feng L*. TNFRSF19 inhibits TGFβ signaling through interaction with TGFβ receptor type I to promote tumorigenesis. Cancer Research, 2018, 78(13): 3469-3483. (IF=12.5)
11. Deng CC#, Xu M#, Li J#, Luo XL, Zhu YJ, Jiang R, Zhang MX, Lei JJ, Lian YF, Zou X, You R,Chen LZ, Feng QS, Bei JX, Chen MY*, Zeng YX*. Unconjugated Bilirubin Is a Novel Prognostic Biomarker for Nasopharyngeal Carcinoma and Inhibits Its Metastasis via Antioxidation Activity. Cancer Prevention Research, 2016, 9(2): 180-188. (IF=2.9)
12. Deng CC, Liang Y, Wu MS, Feng FT, Hu WR, Chen LZ, Feng QS, Bei JX, Zeng YX*. Nigericin selectively targets cancer stem cells in nasopharyngeal carcinoma. The international journal of biochemistry & cell biology, 2013, 45(9): 1997-2006. (IF=3.4)
