Education
Jul 2011 – Jun 2016
Shanghai Jiaotong University Plastic surgery（Doctorate
Work Experience
Jun 2019 – Dec 2024
Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Attending Physician
Jan 2025 – Present
Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Associate Chief Physician
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong
University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, China
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong
University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, China
Customize
Dr. WANG Wenbo has dedicated his career to the clinical treatment and basic research of hypertrophic scars and
keloids since his graduate studies, accumulating 10 years of clinical experience. In recent years, his work has
focused on advancing clinical and fundamental research on pathological scars.
· Clinical Expertise: Development and implementation of comprehensive scar therapies, including surgical
interventions, intralesional drug injections (e.g., corticosteroids, 5-FU), laser therapy, and radiotherapy.
· Basic Research:1.Targeted therapies for keloids (e.g.,nanoparticle-based drug delivery systems).2.Gut
microbiome and metabolic dysregulation in keloid pathogenesis. 3.Collagen remodeling mechanisms and
systemic immune abnormalities in pathological scarring.
Awards: Third Prize, 8th Song Ruyao Youth Forum in Plastic Surgery (2016), recognized for innovative research on
keloid pathophysiology.
Grants: Principal Investigator of one provincial/ministry-level research project and one National Youth Science
Foundation grant.
Publications: Authored 33 SCI-indexed papers in leading international journals such as Bioactive Materials,
Biomaterials, Nano Today, Nano Research, and Dermatologic Therapy ,alongside multiple articles in domestic core
journals.
Active participant in international scar management forums, including the World Congress on Wound Healing
and the International Scar Conference.
Abstract submitted for the 5th International Keloid Symposium
The treatment of keloids, particularly in high-tension areas, is challenging due to their extension beyond the original wound boundaries and high recurrence rates, thereby rendering traditional treatments ineffective. In this study, we investigated the effectiveness of a novel single-stage treatment approach that combines acellular dermal matrix (ADM) with keloid-specific epidermal skin grafting. To further prevent recurrence after neo-skin formation, the treatment was followed by fractionated laser and radiation therapy (LCR). Seven patients with high-tension keloids, including one with keloids at two locations, were treated and followed-up for an average of 15.9 months. The patients showed significant improvements in wound healing and skin appearance, with a marked reduction in the Patient and Observer Scar Assessment Scale (scores from 91.1 ± 5.6 to 23.8 ± 6.1 [p < 0.001]). This approach effectively minimizes tension, reduces the likelihood of keloid recurrence, and serves as a viable alternative to conventional methods that often involve challenges related to donor-site acquisition. No recurrence was observed during the follow-up period, indicating a promising innovation in the management of extensive keloids and offering improved healing and aesthetic outcomes, particularly in high-tension areas.
Keywords: Keloids, acellular dermal matrix, keloid epidermal skin grafting, single-stage treatment, high tension
