Education

2022-2025                       Plastic Surgery                                  Peking Union Medical College Hospital, China

2019-2022               Bachelor of General Surgery             The First Clinical School, Wuhan University, China

2014-2019                      Clinical Medicine                       The First Clinical School, Wuhan University, China

2019 Oct                        Clinical Exchange                    Department of traumatology, Lubinus Clinic, Germany

Publications (# Co-First Author)

1. Kuang XW^#, Luo ZX^#, Chen C. Distinct invasive patterns in situ between estrogen receptor-positive and triple-negative breast cancer through the intraductal tracking of carbon nanoparticles. Int J Cancer. 202(Co-First Author) (IF: 6.4)
2. Kuang XW,Liang ZY, Wang YB. Hydrogen-rich saline combined with vacuum sealing drainage promotes wound healing by altering Biotin metabolism. 2024. (First Author) (IF: 3)
3. Liu Ran, Luo ZX, Dai C, Wei YC, Yan SQ, Kuang XW, Deng ZX.Corynebacterium parakroppenstedtii secretes new glycolipids to promote the development of granulomatous lobular mastitis. (Contributing Author) (IF: 8)
4. Kuang XW^#, Liu JH^#, Chen C. Intraductal Therapy in Breast Cancer: Current Status and Future Prospective. J Mammary Gland Biol Neoplasia. 2020. (Co-First Author) (IF:291)
5. Kuang XW^#, Sun ZH^#, Chen C. Comparison of the ductal carcinoma in situ between White Americans and Chinese Americans. Medicine (Baltimore). 2021.(Co-First Author) (IF: 1.889)
6. Kuang XW^#, Zheng YQ^#, Wang YB, Ma LY.PslG irrigation promotes wound healing and inhibits biofilm formation in a Pseudomonas aeruginosa Murine Skin Model. (Co-First Author) (Under review, International Journal of Biological Macromolecules) (IF: 7)
7. Li WB^#, Kuang XW^#, Shan MJ^#, Wang YB. Effectiveness of Electron Rays in Treating Keloids: Insights from Single-Cell Sequencing. (Co-First Author) (Under review, Int J Radiat Oncol Biol Phys)(IF: 6.4)
8. Kuang XW^#, Liang ZY^#, Wang YB.Therapeutic potential of hydrogen-rich water in keloid patients: A clinical study. (Co-First Author) (Under review, Aesthetic Plastic Surgery) (IF: 0)

Research projects

1. Distinct invasive patterns in situ between estrogen receptor-positive and triple-negative breast cancer through the intraductal tracking of carbon nanoparticles：

The study detected distinct invasion patterns of breast cancer cells between the estrogen receptor-positive and triple-negative breast cancer using two intraductal murine models with intraductal administration of carbon nanoparticles.

• Responsible for: The whole design and accomplishment of the experiment and manuscript.
• Production: The manuscript is now under review (submitted in the International Journal of Nanomedicine).

2. The etiological research of granulomatous mastitis：

The possible causes of granulomatous mastitis and the microorganisms that cause mastitis was investigated using animal models and gene sequencing, and the feasible methods to prevent granulomatous mastitis in daily life were further explored.

• Responsible for: The design and accomplishment of the animal experiment and the draft of related manuscript.
• Production: The manuscript is finished.

3. Enhancedanti–tumor effect of novel water-soluble fulvestrant on breast cancer in vitro and in vivo：

Our study confirmed the activity and anti-tumor effect of the novel water-soluble fulvestrant in vitro and in the intraductal murine models representing the estrogen receptor-positive breast cancer.

• Responsible for: The assistance of the design and accomplishment of the experiment and manuscript.
• Production: Allexperiments are completed and the manuscript drafting is in process.

Abstract submitted for the 5th International Keloid Symposium

Title: A Study on the Multidimensional Effects of Hydrogen-Rich Materials in Wound Healing and the Alleviation of Skin Fibrosis

Authors: Kuang Xinwen (First Author), Liang Zhengyun (Co-author) , Shan Mengjie (Co-author) , Wang Youbin (Co-author)

Affiliation: Department of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

Background:

Wound healing disorders and skin fibrotic lesions (e.g., keloids) are complex clinical challenges often leading to functional impairments. Hydrogen-rich materials, known for their antioxidant, anti-inflammatory, and metabolic regulatory properties, have emerged as promising therapeutic agents. This study evaluates the effects and molecular mechanisms of hydrogen-rich saline (HRS) and hydrogen-rich water (HRW) in wound repair and scar management.

Methods:

Animal Model: A full-thickness skin defect model was created in rabbits, divided into five groups: control, saline, HRS, VSD+saline, and VSD+HRS. Wound healing was assessed via closure rate and histopathological evaluation.

Cell Experiment: Human keratinocyte HaCaT cells were used in vitro to evaluate cell viability.

Metabolomics Analysis: Wound tissue samples underwent untargeted metabolomics analysis to identify differential metabolites and oxidative stress markers.

Clinical Trial: A double-blind randomized controlled trial involved 21 keloid patients, randomized into HRW (11 patients) and control groups (10 patients). Cytokine expression levels and keloid appearance were assessed using Western blotting, qPCR, ELISA, and the Vancouver Scar Scale (VSS).

Ethical Approval: The animal study protocol was approved by the Ethics Committee of Peking Union Medical College Hospital (Approval No.: XHDW-2023-063), and the clinical study passed ethical review (Review No.: ZS-3373). All participants provided informed consent.

Results:

Animal Experiment: The VSD+HRS group showed significantly higher wound healing rates and shorter closure time (p<0.05). HE staining revealed superior epidermal regeneration and granulation tissue formation.

Cell Viability: The VSD+HRS group exhibited significantly higher HaCaT cell viability (p<0.05).

Metabolomics Analysis: Forty-five differential metabolites were identified, with biotin metabolism pathways emerging as potential targets.

Oxidative Stress: VSD+HRS treatment reduced local oxidative stress in wound tissues.

Clinical Trial: HRW significantly reduced postoperative pain and pruritus frequency (p<0.05) and improved VSS and pigmentation scores (p<0.05).

Molecular Mechanisms: HRWT downregulated TRPV1 and HIF-1α expression (p<0.05) and upregulated anti-inflammatory IL-10 (p=0.003), while pro-inflammatory factors IL-6, TGF-β, and VEGF decreased (p=0.030, p=0.002, and p=0.063).

Conclusion:

Hydrogen-rich materials show therapeutic potential in wound healing and keloid management. HRS combined with VSD accelerates wound closure, while HRW therapy alleviates pruritus and promotes inflammation resolution. These findings provide scientific support for the application of hydrogen-rich materials in wound management and skin fibrosis treatment, though further optimization and mechanistic validation are needed.