Xiao Long, MD

Dr. Xiao Long is Associate Professor of Surgery at the Peking Union Medical College Hospital (PUMCH), Division of Plastic and Reconstructive Surgery. She received her doctor’s degree from Peking Union Medical College. She is an active member of the American Society of Plastic Surgeons and serves as the vice chairman of the Youth Committee of the Chinese Medical Association of Plastic Surgeons.

Dr. Long has the special interest in keloid research and management of keloid patients. She is also a member of the editorial board of the Journal of Keloid Research.

Publications

1. A comparison of apoptosis levels in keloid tissue, physiological scars and normal skin. Zhang MZ, Dong XH, Guan EL, Si LB, Zhuge RQ, Zhao PX, Zhang X, Liu MY, Adzavon YM, Long X, Qi Z, Wang X. Am J Transl Res. 2017 Dec 15;9(12):5548-5557.
2. Radiation Therapy in Keloids Treatment: History, Strategy, Effectiveness, and Complication. Xu J, Yang E, Yu NZ, Long X. Chin Med J (Engl). 2017 Jul 20;130(14):1715-1721. doi: 10.4103/0366-6999.209896.
3. Algorithm of chest wall keloid treatment. Long X, Zhang M, Wang Y, Zhao R, Wang Y, Wang X. Medicine (Baltimore). 2016 Aug;95(35):e4684.
4. Increased blood flow in keloids and adjacent skin revealed by laser speckle contrast imaging. Liu Q, Wang X, Jia Y, Long X, Yu N, Wang Y, Chen B. Lasers Surg Med. 2016 Apr;48(4):360-4. doi: 10.1002/lsm.22470.
5. LncRNA expression profiles and validation in keloid and normal skin tissue. Liang X, Ma L, Long X, Wang X. Int J Oncol. 2015 Nov;47(5):1829-38.
6. 2ME2 increase radiation-induced apoptosis of keloid fibroblasts by targeting HIF-1α in vitro. Long F, Si L, Long X, Yang B, Wang X, Zhang F. Australas J Dermatol. 2016 May;57(2):e32-8. doi: 10.1111/ajd.12340
7. Keloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxic microenvironment in vitro. Ma X, Chen J, Xu B, Long X, Qin H, Zhao RC, Wang X. Int J Mol Med. 2015 May;35(5):1246-56. doi: 10.3892/ijmm.2015.2135.
8. [An individualized approach combining local flaps with radiotherapy for the treatment of auricle keloid]. Long X, Wang XJ, Wang YB, Li WB, Sun XS. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Apr;35(2):213-6. doi: 10.3881/j.issn.1000-503X.2013.02.015.
9. “X”-shaped incision and keloid skin-flap resurfacing: a new surgical method for auricle keloidexcision and reconstruction. Qi Z, Liang W, Wang Y, Long X, Sun X, Wang X, Zhao Z, Zhou Z, Qiao Q. Dermatol Surg. 2012 Aug;38(8):1378-82.
10. Influence of quercetin and x-ray on collagen synthesis of cultured human keloid-derived fibroblasts. Long X, Zeng X, Zhang FQ, Wang XJ. Chin Med Sci J. 2006 Sep;21(3):179-83.

Abstract submitted for the 5th International Keloid Symposium

Deciphering the cellular landscape of pathological scars

Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Pathological scars (PS) are characterized by excess dermal collagen deposition, primarily manifesting as hypertrophic scars and keloids. The microenvironment of PS is shaped by a diverse array of cells, collectively forming a pro-fibrotic and pro-angiogenic niche. Recent advances in high-throughput sequencing have enhanced our understanding of the cellular heterogeneity, transcriptional changes, and intercellular communication within the PS microenvironment. This review comprehensively describes the cellular landscape of pathological scars, including epithelial cells (keratinocytes and melanocytes), mesenchymal cells (fibroblasts, mesenchymal stem cells and Schwann cells), endothelial cells (vascular endothelial cells and lymphatic endothelial cells), and immune cells (macrophages, mast cells, B lymphocytes, T lymphocytes, natural killer cells and dendritic cells). The focus is on important cellular events, phenotypic changes, and the interactions between fibroblasts and other cells within the PS microenvironment. The aim is to provide a foundation for identifying therapeutic targets for the treatment of pathological scars.